197 Second primary cancer risk after diagnosis of melanoma by subtype
نویسندگان
چکیده
Background: Survivors of cutaneous melanoma (CM) have an increased risk for developing multiple cancers, including melanoma, breast cancer, prostate and non-Hodgkin lymphoma (NHL). Limited data exists comparing differences in second primary cancer (SPC) between CM subtypes. Purpose: To compare the spectrum SPC subtypes (superficial spreading, SSM; lentigo maligna, LMM; acral lentiginous, ALM; nodular, NM; desmoplastic, DM; amelanotic, AM). Methods: Using Surveillance, Epidemiology, End Results (SEER) 18 (2000-2018), we calculated by subtype. Analyses were restricted to individuals with a first (no prior malignancies) diagnosis CM. Results: Of 172,637 survivors, 20,696 (12 %) developed SPC, corresponding nearly two-fold (standardized incidence ratio [SIR] 1.73, 95% confidence interval [CI] 1.71-1.76) compared general population. was highest NM (SIR 2.11, CI 2.03-2.18) lowest LMM (1.55, 1.50-1.61). Across all subtypes, there NHL range: 1.38 [LMM]-2.19 [AM]) 10.52 [LMM]-16.80 [AM]). Risk thyroid 1.52 [LMM]-3.19 [NM]) except AM. Prostate elevated after SSM 1.24, 1.18-1.31), (1.15, 1.02-1.29), (1.21, 1.10-1.32). following 1.13, 1.06-1.20), but not other Kidney also 2.09, 1.70-2.55) (1.33, 1.19-1.48). Conclusions: The varies according Germline variation susceptibility genes may partially explain these patterns risk. Our study supports current practice intensive skin surveillance survivors given highly each
منابع مشابه
Increased risk of second primary cancers after a diagnosis of melanoma.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.05.204