197 Second primary cancer risk after diagnosis of melanoma by subtype

نویسندگان

چکیده

Background: Survivors of cutaneous melanoma (CM) have an increased risk for developing multiple cancers, including melanoma, breast cancer, prostate and non-Hodgkin lymphoma (NHL). Limited data exists comparing differences in second primary cancer (SPC) between CM subtypes. Purpose: To compare the spectrum SPC subtypes (superficial spreading, SSM; lentigo maligna, LMM; acral lentiginous, ALM; nodular, NM; desmoplastic, DM; amelanotic, AM). Methods: Using Surveillance, Epidemiology, End Results (SEER) 18 (2000-2018), we calculated by subtype. Analyses were restricted to individuals with a first (no prior malignancies) diagnosis CM. Results: Of 172,637 survivors, 20,696 (12 %) developed SPC, corresponding nearly two-fold (standardized incidence ratio [SIR] 1.73, 95% confidence interval [CI] 1.71-1.76) compared general population. was highest NM (SIR 2.11, CI 2.03-2.18) lowest LMM (1.55, 1.50-1.61). Across all subtypes, there NHL range: 1.38 [LMM]-2.19 [AM]) 10.52 [LMM]-16.80 [AM]). Risk thyroid 1.52 [LMM]-3.19 [NM]) except AM. Prostate elevated after SSM 1.24, 1.18-1.31), (1.15, 1.02-1.29), (1.21, 1.10-1.32). following 1.13, 1.06-1.20), but not other Kidney also 2.09, 1.70-2.55) (1.33, 1.19-1.48). Conclusions: The varies according Germline variation susceptibility genes may partially explain these patterns risk. Our study supports current practice intensive skin surveillance survivors given highly each

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ژورنال

عنوان ژورنال: Journal of Investigative Dermatology

سال: 2022

ISSN: ['1523-1747', '0022-202X']

DOI: https://doi.org/10.1016/j.jid.2022.05.204